In 1722 Thomas Lamboll purchased the land for his house. The Lands extended to the north line of 25 King Street to the Cooper River and to the Ashley River. It included White Point Gardens where The Lamboll's had a large Rose Garden accessible only by boat. Mr. and Mr. Lamboll were noted botanist and also had an extensive botanical garden on the southwest corner of King and Lamboll Street that extended to the harbor.
Thomas Lamboll died in 1774. After his death, his daughter, Mary Lamboll Thomas, inherited the property. Eventually it was acquired by the City Council of Charleston for the straightening and widening of Lamboll Street.
In 1849 the house and lot were purchased by Patrick O'Donnell, and the building moved about 20 feet north to its present site. Mr. O'Donnell chose this house for a temporary residence while he supervised the construction of 21 King Street immediately to the north. Apparently his stay at 19 King was not temporary enough - O'Donnells bride-to-be (for whom he was building the new house) chose to marry another man before the building could be completed.
The Lamboll House a notable example of pre-Revolutionary architecture, which also shows evidence of later attempts of change. Many architectural periods are represented- ranging from the early Georgian to the Victorian period. The house, which is now over 250 years old, is a good example of the way in which old Charleston homes have adapted to newer styles without losing their original character and charm.